Mouse aorta smooth muscle cells differentiate into lymphoid tissue organizer-like cells on combined tumor necrosis factor receptor-1/lymphotoxin beta-receptor NF-kappaB signaling.

@article{Ltzer2010MouseAS,
  title={Mouse aorta smooth muscle cells differentiate into lymphoid tissue organizer-like cells on combined tumor necrosis factor receptor-1/lymphotoxin beta-receptor NF-kappaB signaling.},
  author={Katharina L{\"o}tzer and Sandra Doepping and Sabine Connert and Rolf Graebner and Rainer Spanbroek and Birgit Lemser and Michael R. Beer and Markus Hildner and Thomas Hehlgans and Michael van der Wall and Reina E Mebius and Agnes Lovas and Gwendalyn J Randolph and Falk Weih and Andreas J. R. Habenicht},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2010},
  volume={30 3},
  pages={395-402}
}
OBJECTIVE Mouse aorta smooth muscle cells (SMC) express tumor necrosis factor receptor superfamily member 1A (TNFR-1) and lymphotoxin beta-receptor (LTbetaR). Circumstantial evidence has linked the SMC LTbetaR to tertiary lymphoid organogenesis in hyperlipidemic mice. Here, we explored TNFR-1 and LTbetaR signaling in cultured SMC. METHODS AND RESULTS TNFR-1 signaling activated the classical RelA NF-kappaB pathway, whereas LTbetaR signaling activated the classical RelA and alternative RelB NF… CONTINUE READING
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