Mouse adenovirus type 1 attachment is not mediated by the coxsackie-adenovirus receptor.

@article{Lenaerts2006MouseAT,
  title={Mouse adenovirus type 1 attachment is not mediated by the coxsackie-adenovirus receptor.},
  author={Liesbeth Lenaerts and Dirk Daelemans and Nick Geukens and Erik de Clercq and Lieve M J Naesens},
  journal={FEBS letters},
  year={2006},
  volume={580 16},
  pages={3937-42}
}
Common human adenovirus (Ad) vectors are derived from serotype 2 or 5, which use the coxsackie-adenovirus receptor (CAR) as their primary cell receptor. We investigated the receptor usage of mouse adenovirus type 1 (MAV-1), which in vivo is characterized by a pronounced endothelial cell tropism. Alignment of the fiber knob sequences of MAV-1 and those of CAR-using adenoviruses, revealed that amino acid residues, critical for interaction with CAR, are not conserved in the MAV-1 fiber knob… CONTINUE READING