Mouse-adapted scrapie infection of SN56 cells: greater efficiency with microsome-associated versus purified PrP-res.

@article{Baron2006MouseadaptedSI,
  title={Mouse-adapted scrapie infection of SN56 cells: greater efficiency with microsome-associated versus purified PrP-res.},
  author={Gerald S. Baron and Ana Cristina Magalh{\~a}es and Marco A M Prado and Byron Caughey},
  journal={Journal of virology},
  year={2006},
  volume={80 5},
  pages={2106-17}
}
The process by which transmissible spongiform encephalopathy agents, or prions, infect cells is unknown. We employed a new differentiable cell line (SN56) susceptible to infection with three mouse-adapted scrapie strains to gain insight into the cellular infection process. The effect of disease-associated PrP (PrP-res) association with microsomal membranes on infection efficiency was examined by comparing sustained PrP-res production in cells treated with either scrapie brain microsomes or… CONTINUE READING

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