Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives.

@article{Inoue2004MouseZD,
  title={Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives.},
  author={Takashi Inoue and Minoru Hatayama and Takahide Tohmonda and Shigeyoshi Itohara and Jun Aruga and Katsuhiko Mikoshiba},
  journal={Developmental biology},
  year={2004},
  volume={270 1},
  pages={146-62}
}
Zic family genes encode zinc finger proteins, which are homologues of the Drosophila pair-rule gene odd-paired. In the present study, we characterized the fifth member of the mouse Zic family gene, mouse Zic5. Zic5 is located near Zic2, which is responsible for human brain malformation syndrome (holoprosencephaly, or HPE). In embryonic stages, Zic5 was expressed in dorsal part of neural tissues and limbs. Expression of Zic5 overlapped with those of other Zic genes, most closely with Zic2, but… CONTINUE READING

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