Mouse Zic1 is involved in cerebellar development.

  title={Mouse Zic1 is involved in cerebellar development.},
  author={Jun Aruga and Osamu Minowa and Hiroyuki Yaginuma and Junko Kuno and Takeharu Nagai and Tetsuo Noda and Katsuhiko Mikoshiba},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={18 1},
Zic genes encode zinc finger proteins, the expression of which is highly restricted to cerebellar granule cells and their precursors. These genes are homologs of the Drosophila pair-rule gene odd-paired. To clarify the role of the Zic1 gene, we have generated mice deficient in Zic1. Homozygous mice showed remarkable ataxia during postnatal development. Nearly all of the mice died within 1 month. Their cerebella were hypoplastic and missing a lobule in the anterior lobe. A bromodeoxyuridine… CONTINUE READING