Mouse Studies Question Importance of Toll-Like Receptors to Vaccines

  title={Mouse Studies Question Importance of Toll-Like Receptors to Vaccines},
  author={Ingrid Wickelgren},
  pages={1859 - 1860}
IMMUNOLOGY Toll-like receptors (TLRs), once an obscure class of cell-surface proteins, have become hot targets for drugs and vaccines. And many immunologists have come to regard these key microbial sensors as the long-sought link between the immune system's initial inflammatory response and its more tailored and enduring antibody and cellular response ( Science , 14 April, p. [184][1]). Now, however, a new study casts doubt on the importance of TLRs as general-purpose immune stimulators… 
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