Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis.


In humans, holoprosencephaly (HPE) is a common birth defect characterized by the absence of midline cells from brain, facial, and oral structures. To understand the pathoetiology of HPE, we investigated the involvement of mammalian prechordal plate (PrCP) cells in HPE pathogenesis and the requirement of the secreted protein sonic hedgehog (Shh) in PrCP… (More)
DOI: 10.1016/j.ydbio.2008.11.022


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