Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis.

@article{Aoto2009MouseSI,
  title={Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis.},
  author={Kazushi Aoto and Yayoi Shikata and Hajime Imai and Daisuke Matsumaru and Tomoyuki Tokunaga and Seiji Shioda and Gen Yamada and Jun Motoyama},
  journal={Developmental biology},
  year={2009},
  volume={327 1},
  pages={106-20}
}
In humans, holoprosencephaly (HPE) is a common birth defect characterized by the absence of midline cells from brain, facial, and oral structures. To understand the pathoetiology of HPE, we investigated the involvement of mammalian prechordal plate (PrCP) cells in HPE pathogenesis and the requirement of the secreted protein sonic hedgehog (Shh) in PrCP development. We show using rat PrCP lesion experiments and DiI labeling that PrCP cells are essential for midline development of the forebrain… CONTINUE READING