Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair

@article{Hodskinson2014MouseSI,
  title={Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair},
  author={Michael R G Hodskinson and J. Silhan and Gerry P Crossan and J. I. Garaycoechea and S. Mukherjee and C. Johnson and O. Sch{\"a}rer and K. Patel},
  journal={Molecular Cell},
  year={2014},
  volume={54},
  pages={472 - 484}
}
Summary SLX4 binds to three nucleases (XPF-ERCC1, MUS81-EME1, and SLX1), and its deficiency leads to genomic instability, sensitivity to DNA crosslinking agents, and Fanconi anemia. However, it is not understood how SLX4 and its associated nucleases act in DNA crosslink repair. Here, we uncover consequences of mouse Slx4 deficiency and reveal its function in DNA crosslink repair. Slx4-deficient mice develop epithelial cancers and have a contracted hematopoietic stem cell pool. The N-terminal… Expand
110 Citations
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