Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response.

@article{Behrendt2013MouseSH,
  title={Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response.},
  author={Rayk Behrendt and Tina Schumann and Alexander Gerbaulet and Laura Anh Nguyen and Nadja Schubert and Dimitra Alexopoulou and Ursula Berka and Stefan Lienenklaus and Katrin Peschke and Kathrin Gibbert and Sabine Wittmann and Dirk Lindemann and Siegfried Weiss and Andreas R. Dahl and Ronald Naumann and Ulf Dittmer and Baek ki Kim and Werner M{\"u}ller and Thomas Gramberg and Axel Roers},
  journal={Cell reports},
  year={2013},
  volume={4 4},
  pages={689-96}
}
Aicardi-Goutières syndrome (AGS), a hereditary autoimmune disease, clinically and biochemically overlaps with systemic lupus erythematosus (SLE) and, like SLE, is characterized by spontaneous type I interferon (IFN) production. The finding that defects of intracellular nucleases cause AGS led to the concept that intracellular accumulation of nucleic acids triggers inappropriate production of type I IFN and autoimmunity. AGS can also be caused by defects of SAMHD1, a 3' exonuclease and… CONTINUE READING
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