Mouse Rankl expression is regulated in T cells by c-Fos through a cluster of distal regulatory enhancers designated the T cell control region.

@article{Bishop2011MouseRE,
  title={Mouse Rankl expression is regulated in T cells by c-Fos through a cluster of distal regulatory enhancers designated the T cell control region.},
  author={Kathleen A. Bishop and Heidi Coy and Robert D Nerenz and Mark B. Meyer and John Wesley Pike},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 23},
  pages={20880-91}
}
Receptor activator of NF-κB ligand (Rankl) is a TNF-like factor that induces the formation of osteoclasts responsible for bone resorption. Although T cell activation up-regulates this gene, the molecular mechanism of its transcriptional control remains unknown. We used ChIP-chip analysis in mouse primary T cells and a T cell hybridoma to define the regulatory enhancers responsible for this up-regulation and to characterize their properties. Elevated H3/H4 acetylation and increased RNA… CONTINUE READING

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