Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons

@article{Giese1992MousePG,
  title={Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons},
  author={K. Giese and R. Martini and G. Lemke and Philippe Soriano and M. Schachner},
  journal={Cell},
  year={1992},
  volume={71},
  pages={565-576}
}
  • K. Giese, R. Martini, +2 authors M. Schachner
  • Published 1992
  • Biology, Medicine
  • Cell
  • We have used homologous recombination in embryonic stem cells to generate mice carrying a mutation in the gene encoding P0, an immunoglobulin-related recognition molecule and the major protein of peripheral nervous system myelin. These mice are deficient in normal motor coordination and exhibit tremors and occasional convulsions. Axons in their peripheral nerves are severely hypomyelinated and a subset of myelin-like figures and axons degenerate. The mutation leads to an abnormal regulation of… CONTINUE READING
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