Mouse Muscle As an Ectopic Permissive Site for Human Pancreatic Development

@inproceedings{Capito2013MouseMA,
  title={Mouse Muscle As an Ectopic Permissive Site for Human Pancreatic Development},
  author={C A R M E Capito and M. Simon and Virginie Aiello and Anne Clark and Yves Aigrain and Philippe Ravassard and Rapha{\"e}l Scharfmann},
  booktitle={Diabetes},
  year={2013}
}
While sporadic human genetic studies have permitted some comparisons between rodent and human pancreatic development, the lack of a robust experimental system has not permitted detailed examination of human pancreatic development. We previously developed a xenograft model of immature human fetal pancreas grafted under the kidney capsule of immune-incompetent mice, which allowed the development of human pancreatic β-cells. Here, we compared the development of human and murine fetal pancreatic… CONTINUE READING