Mouse Models to Study Dengue Virus Immunology and Pathogenesis

  title={Mouse Models to Study Dengue Virus Immunology and Pathogenesis},
  author={Rapha{\"e}l M. Zellweger and Sujan Shresta},
  booktitle={Front. Immunol.},
The development of a compelling murine model of dengue virus (DENV) infection has been challenging, because DENV clinical isolates do not readily replicate or cause pathology in immunocompetent mice. However, research using immunocompromised mice and/or mouse-adapted viruses allows investigation of questions that may be impossible to address in human studies. In this review, we discuss the potential strengths and limitations of existing mouse models of dengue disease. Human studies are… CONTINUE READING
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