Mouse Models of Spinocerebellar Ataxia Type 3 (Machado-Joseph Disease)

  title={Mouse Models of Spinocerebellar Ataxia Type 3 (Machado-Joseph Disease)},
  author={Veronica F. Colomer Gould},
Machado-Joseph disease, also called spinocerebellar ataxia type 3 (MJD/SCA3), is a hereditary and neurodegenerative movement disorder caused by ataxin-3 with a pathological polyglutamine stretch (mutant ataxin-3). Seven transgenic mouse models expressing full-length human mutant ataxin-3 throughout the brain have been generated and are compared in this review. They vary in the corresponding transgenic DNA constructs with differences that include the encoded human ataxin-3 isoform(s), number of… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS


Publications referenced by this paper.
Showing 1-10 of 55 references

Similar Papers

Loading similar papers…