Mouse Models of Sepsis and Septic Shock

  title={Mouse Models of Sepsis and Septic Shock},
  author={Kirill V Korneev},
  journal={Molecular Biology},
  pages={704 - 717}
  • K. Korneev
  • Published 1 September 2019
  • Biology
  • Molecular Biology
An extensive network of regulation of systemic inflammation makes development of a reproducible experimental model of sepsis a complex task. There is no single mouse model that can capture all clinical aspects of this complicated pathology. However, a combination of existing approaches can go a long way towards analysis of specific mechanisms of sepsis development and to the design of novel therapeutic approaches. This review describes the popular mouse models of sepsis and septic shock, as… 
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Model organisms: Animal Models of sepsis: setting the stage
This review summarizes the common animal sepsis models and highlights how results of recent human clinical trials might affect their use.
Differences between murine and human sepsis.
Harmful molecular mechanisms in sepsis
This Review highlights recent insights into the molecular interactions that occur during sepsis and attempts to unravel the nature of the dysregulated immune response duringSepsis.
The disconnect between animal models of sepsis and human sepsis
The shortcomings of the animal models are described and reasons why effective therapy for human sepsis cannot be derived readily from promising findings in animal sepsi are described.
Differential Paradigms in Animal Models of Sepsis
The underlying mechanisms regulating each of these models of sepsis are discussed along with possible reasons why each model failed to translate into the clinic and better understanding of the existing models could help create a more relevant model which could provide solution to the currently failed clinical trials in sepsi.
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The future of murine sepsis and trauma research models
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