Mouse Models of Pediatric Supratentorial High-grade Glioma Reveal How Cell-of-Origin Influences Tumor Development and Phenotype.

@article{Sreedharan2017MouseMO,
  title={Mouse Models of Pediatric Supratentorial High-grade Glioma Reveal How Cell-of-Origin Influences Tumor Development and Phenotype.},
  author={Smitha Sreedharan and Naga Prathyusha Maturi and Yuan Xie and Anders Sundstr{\"o}m and Malin Jarvius and Sylwia Libard and Irina Alafuzoff and Holger Weishaupt and M{\aa}rten Frykn{\"a}s and Rolf Larsson and Fredrik J Swartling and Lene Uhrbom},
  journal={Cancer research},
  year={2017},
  volume={77 3},
  pages={802-812}
}
High-grade glioma (HGG) is a group of primary malignant brain tumors with dismal prognosis. Whereas adult HGG has been studied extensively, childhood HGG, a relatively rare disease, is less well-characterized. Here, we present two novel platelet-derived growth factor (PDGF)-driven mouse models of pediatric supratentorial HGG. Tumors developed from two… CONTINUE READING