Mouse Models of Down Syndrome as a Tool to Unravel the Causes of Mental Disabilities

@inproceedings{Rueda2012MouseMO,
  title={Mouse Models of Down Syndrome as a Tool to Unravel the Causes of Mental Disabilities},
  author={N. Martinez Rueda and Jes{\'u}s Fl{\'o}rez and Carmen Mart{\'i}nez-Cu{\'e}},
  booktitle={Neural plasticity},
  year={2012}
}
Down syndrome (DS) is the most common genetic cause of mental disability. Based on the homology of Hsa21 and the murine chromosomes Mmu16, Mmu17 and Mmu10, several mouse models of DS have been developed. The most commonly used model, the Ts65Dn mouse, has been widely used to investigate the neural mechanisms underlying the mental disabilities seen in DS individuals. A wide array of neuromorphological alterations appears to compromise cognitive performance in trisomic mice. Enhanced inhibition… CONTINUE READING