Mouse MHC class I-like Fc receptor encoded outside the MHC.

  title={Mouse MHC class I-like Fc receptor encoded outside the MHC.},
  author={J J Ahouse and C L Hagerman and Pooja Mittal and Debra J. Gilbert and Neal G. Copeland and Nancy A. Jenkins and Neil E. Simister},
  journal={Journal of immunology},
  volume={151 11},
In many mammalian species antibodies transmitted from the mother provide humoral immunity to the young. Maternal IgG from milk is transported across the intestinal epithelium of neonatal rats by an Fc receptor (FcRn) that comprises an alpha-chain similar to the class I Ag of the MHC and beta 2-microglobulin. Suckling mice also acquire antibodies by uptake from the gut. We made a neonatal mouse intestinal cDNA library and screened it with a probe encoding rat FcRn alpha-chain. The nucleotide and… CONTINUE READING