Mouse Leydig cells express multiple P2X receptor subunits

@article{Antonio2008MouseLC,
  title={Mouse Leydig cells express multiple P2X receptor subunits},
  author={Ligia Subitoni Antonio and Roberta Ribeiro Costa and Marcelo Dam{\'a}rio Gomes and Wamberto Antonio Varanda},
  journal={Purinergic Signalling},
  year={2008},
  volume={5},
  pages={277-287}
}
ATP acts on cellular membranes by interacting with P2X (ionotropic) and P2Y (metabotropic) receptors. Seven homomeric P2X receptors (P2X1–P2X7) and seven heteromeric receptors (P2X1/2, P2X1/4, P2X1/5, P2X2/3, P2X2/6, P2X4/6, P2X4/7) have been described. ATP treatment of Leydig cells leads to an increase in [Ca2+]i and testosterone secretion, supporting the hypothesis that Ca2+ signaling through purinergic receptors contributes to the process of testosterone secretion in these cells. Mouse… CONTINUE READING

Citations

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Purinergic Signalling in the Reproductive System

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  • Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 2018
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