Mouse Hyal3 encodes a 45- to 56-kDa glycoprotein whose overexpression increases hyaluronidase 1 activity in cultured cells.

@article{Hemming2008MouseHE,
  title={Mouse Hyal3 encodes a 45- to 56-kDa glycoprotein whose overexpression increases hyaluronidase 1 activity in cultured cells.},
  author={Richard J Hemming and Dianna C Martin and Elzbieta Slominski and J. I. Nagy and Andrew J Halayko and Steven Pind and Barbara Triggs-Raine},
  journal={Glycobiology},
  year={2008},
  volume={18 4},
  pages={280-9}
}
Hyaluronidases are enzymes that mediate the breakdown of hyaluronan (HA), a large polysaccharide abundant in the extracellular matrix of vertebrate tissues. Six genes have been predicted to encode hyaluronidases in humans, but the protein products of only SPAM1, HYAL1, and HYAL2 have been characterized. We have now expressed the mouse Hyal3 gene product, hyaluronidase 3 (Hyal3), in Baby Hamster Kidney (BHK) cells and demonstrated the presence of multiple forms of Hyal3 ranging from… CONTINUE READING