Mouse Flk-1+Sca-1- mesenchymal stem cells: functional plasticity in vitro and immunoregulation in vivo.

@article{Xishan2014MouseFM,
  title={Mouse Flk-1+Sca-1- mesenchymal stem cells: functional plasticity in vitro and immunoregulation in vivo.},
  author={Zhu Xishan and Yu Haojun and He Baoxin and Zhou Xinna and Jiang Ni and Zhang Hongmei and Wang Xiaoli and Ren Jun},
  journal={Transplantation},
  year={2014},
  volume={97 5},
  pages={509-17}
}
OBJECTIVES Mesenchymal stem cells (MSCs) represent a powerful tool in regenerative medicine because of their differentiation and migration capacities. Moreover, the immunomodulatory ability of MSCs may be used to develop therapies for the treatment of autoimmune diseases. METHODS In this study, we isolated Flk-1Sca-1 MSCs from bone marrow (bMSCs). Next, we studied their biological characteristics and immunologic functions. We also investigated their effects on graft-versus-host disease (GVHD… CONTINUE READING
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