Mouse Fgf8-Cre-LacZ lineage analysis defines the territory of the postnatal mammalian isthmus.

@article{Watson2017MouseFL,
  title={Mouse Fgf8-Cre-LacZ lineage analysis defines the territory of the postnatal mammalian isthmus.},
  author={Charles Watson and Tomomi Shimogori and Luis Puelles},
  journal={The Journal of comparative neurology},
  year={2017},
  volume={525 12},
  pages={2782-2799}
}
The isthmus is recognized as the most rostral segment of the hindbrain in non-mammalian vertebrates. In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. We attempted to find if the region of early embryonic Fgf8 expression (which is considered to involve the entire extent of the prospective isthmus… CONTINUE READING
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