Mouse Embryonic Fibroblasts (MEF) Exhibit a Similar but not Identical Phenotype to Bone Marrow Stromal Stem Cells (BMSC)

@article{Saeed2011MouseEF,
  title={Mouse Embryonic Fibroblasts (MEF) Exhibit a Similar but not Identical Phenotype to Bone Marrow Stromal Stem Cells (BMSC)},
  author={Hamid Saeed and Hanna Taipaleenm{\"a}ki and Abdullah Aldahmash and Basem M. Abdallah and Moustapha Kassem},
  journal={Stem Cell Reviews and Reports},
  year={2011},
  volume={8},
  pages={318-328}
}
Mouse embryonic fibroblasts have been utilized as a surrogate stem cell model for the postnatal bone marrow-derived stromal stem cells (BMSC) to study mesoderm-type cell differentiation e.g. osteoblasts, adipocytes and chondrocytes. However, no formal characterization of MEF phenotype has been reported. Utilizing standard in vitro and in vivo assays we performed a side-by-side comparison of MEF and BMSC to determine their ability to differentiate into mesoderm-type cells. BMSC were isolated… CONTINUE READING
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