Mouse Elovl-6 promoter is an SREBP target.

  title={Mouse Elovl-6 promoter is an SREBP target.},
  author={Shin Kumadaki and Takashi Matsuzaka and Toyonori Kato and Naoya Yahagi and Takashi Yamamoto and Sumiyo Okada and Kazuto Kobayashi and Akimitsu Takahashi and Shigeru Yatoh and Hiroaki Suzuki and Nobuhiro Yamada and Hitoshi Shimano},
  journal={Biochemical and biophysical research communications},
  volume={368 2},
Elovl-6, a long fatty acid elongase, contributes to de novo synthesis of fatty acids and regulates hepatic insulin sensitivity. Hepatic regulation of Elovl-6 gene expression in various nutritional conditions suggested that, like other lipogenic enzyme genes, Elovl-6 is a target of SREBP-1, a transcription factor governing fatty acid synthesis. Supportively, adenoviral RNAi knockdown of SREBP-1 in mouse liver suppressed Elovl-6 mRNA and fatty acid synthase levels. Therefore, we analyzed mouse… CONTINUE READING
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