Mouse ECG findings in aging, with conduction system affecting drugs and in cardiac pathologies: Development and validation of ECG analysis algorithm in mice.

@article{Merentie2015MouseEF,
  title={Mouse ECG findings in aging, with conduction system affecting drugs and in cardiac pathologies: Development and validation of ECG analysis algorithm in mice.},
  author={Mari Merentie and Jukka Antero Lipponen and Marja K Hedman and Antti Hedman and Juha E.K. Hartikainen and Jenni Huusko and Line Lottonen-Raikaslehto and Viktor Parviainen and Svetlana Laidinen and Pasi A. Karjalainen and Seppo Yl{\"a}-Herttuala},
  journal={Physiological reports},
  year={2015},
  volume={3 12}
}
Mouse models are extremely important in studying cardiac pathologies and related electrophysiology, but very few mouse ECG analysis programs are readily available. Therefore, a mouse ECG analysis algorithm was developed and validated. Surface ECG (lead II) was acquired during transthoracic echocardiography from C57Bl/6J mice under isoflurane anesthesia. The effect of aging was studied in young (2-3 months), middle-aged (14 months) and old (20-24 months) mice. The ECG changes associated with… CONTINUE READING