Mouse CD23 regulates monocyte activation through an interaction with the adhesion molecule CD11b/CD18.

@article{LecoanetHenchoz1997MouseCR,
  title={Mouse CD23 regulates monocyte activation through an interaction with the adhesion molecule CD11b/CD18.},
  author={Sybille Lecoanet-Henchoz and Christine Plater-Zyberk and Pierre Graber and Denise Gretener and Jean Pierre Aubry and Daniel H Conrad and Jean Yves Bonnefoy},
  journal={European journal of immunology},
  year={1997},
  volume={27 9},
  pages={
          2290-4
        }
}
CD23 is expressed on a variety of hemopoietic cells. Recently, we have reported that blocking CD23 interactions in a murine model of arthritis resulted in a marked improvement of disease severity. Here, we demonstrate that CD11b, the alpha chain of the beta 2 integrin adhesion molecule complex CD11b/CD18 expressed on monocytes interacts with CD23. Using a recombinant fusion protein (ZZ-CD23), murine CD23 was shown to bind to peritoneal macrophages and peripheral blood cells isolated from mice… CONTINUE READING
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