Motorneurons Require Cysteine String Protein-α to Maintain the Readily Releasable Vesicular Pool and Synaptic Vesicle Recycling

@article{Rozas2012MotorneuronsRC,
  title={Motorneurons Require Cysteine String Protein-α to Maintain the Readily Releasable Vesicular Pool and Synaptic Vesicle Recycling},
  author={Jos{\'e} Luis Rozas and Leonardo G{\'o}mez-S{\'a}nchez and Josif Mircheski and Pedro Linares-Clemente and Jose Luis Nieto-Gonzalez and M Eugenio V{\'a}zquez and Rafael Luj{\'a}n and Rafael Fern{\'a}ndez-Chac{\'o}n},
  journal={Neuron},
  year={2012},
  volume={74},
  pages={151-165}
}
Cysteine string protein-α (CSP-α) is a synaptic vesicle protein that prevents activity-dependent neurodegeneration by poorly understood mechanisms. We have studied the synaptic vesicle cycle at the motor nerve terminals of CSP-α knock-out mice expressing the synaptopHluorin transgene. Mutant nerve terminals fail to sustain prolonged release and the number of vesicles available to be released decreases. Strikingly, the SNARE protein SNAP-25 is dramatically reduced. In addition, endocytosis… CONTINUE READING
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