Motorized RhoGAP myosin IXb (Myo9b) controls cell shape and motility.

@article{Hanley2010MotorizedRM,
  title={Motorized RhoGAP myosin IXb (Myo9b) controls cell shape and motility.},
  author={Peter J. Hanley and Yan Xu and Moritz Kronlage and Kay Grobe and Peter Manfred Sch{\"o}n and Jian tao Song and Lydia Sorokin and Albrecht Schwab and Martin B{\"a}hler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 27},
  pages={
          12145-50
        }
}
Directional motility is a fundamental function of immune cells, which are recruited to sites of pathogen invasion or tissue damage by chemoattractant signals. To move, cells need to generate lamellipodial membrane protrusions at the front and retract the trailing end. These elementary events are initiated by Rho-family GTPases, which cycle between active GTP-bound and inactive GDP-bound states. How the activity of these "molecular switches" is spatially coordinated is only beginning to be… CONTINUE READING

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