Motor system plasticity in stroke models: intrinsically use-dependent, unreliably useful.

  title={Motor system plasticity in stroke models: intrinsically use-dependent, unreliably useful.},
  author={Theresa A. Jones and Rachel Patrice Allred and Stephanie C Jefferson and Abigail L Kerr and Daniel A Woodie and S Y Cheng and DeAnna L Adkins},
  volume={44 6 Suppl 1},
F unctional impairment is a powerful incentive for behav-ioral change. The natural response to disability in one limb is to learn new ways of using the other limb. Animals, including humans, with upper extremity impairments spontaneously learn to use the less-affected (nonparetic) hand in novel ways to perform daily activities. In intact brains, the acquisition of manual skills depends on practice-dependent synaptic structural and functional reorganization of motor cortex (MC). After stroke… CONTINUE READING
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A role for ephrin-A5 in axonal sprouting, recovery, and activity-dependent plasticity after stroke.

Proceedings of the National Academy of Sciences of the United States of America • 2012

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