Motor-skill learning in a novel running-wheel task is dependent on D1 dopamine receptors in the striatum

@article{Willuhn2008MotorskillLI,
  title={Motor-skill learning in a novel running-wheel task is dependent on D1 dopamine receptors in the striatum},
  author={Ingo Willuhn and Hermann-J. Steiner},
  journal={Neuroscience},
  year={2008},
  volume={153},
  pages={249-258}
}
Evidence indicates that dopamine receptors regulate processes of procedural learning in the sensorimotor striatum. Our previous studies revealed that the indirect dopamine receptor agonist cocaine alters motor-skill learning-associated gene regulation in the sensorimotor striatum. Cocaine-induced gene regulation in the striatum is principally mediated by D1 dopamine receptors. We investigated the effects of cocaine and striatal D1 receptor antagonism on motor-skill learning. Rats were trained… CONTINUE READING
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