Motor performance and regional brain metabolism of spontaneous murine mutations with cerebellar atrophy.

@article{Lalonde2001MotorPA,
  title={Motor performance and regional brain metabolism of spontaneous murine mutations with cerebellar atrophy.},
  author={Robert Lalonde and Catherine Strazielle},
  journal={Behavioural brain research},
  year={2001},
  volume={125 1-2},
  pages={103-8}
}
Three spontaneous mutations with cerebellar atrophy were evaluated for motor coordination and regional brain metabolism, as assessed by cytochrome oxidase (CO) activity. Despite similar neuropathological characteristics, the behavioral phenotype of Lurcher is less severe than that of staggerer, possibly caused by the slower onset of their neuronal degeneration. Although fewer cerebellar cells degenerate in hot-foot than in Lurcher, their motor deficits are more severe, indicating the presence… CONTINUE READING

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