Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

@article{Reaume1996MotorNI,
  title={Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury},
  author={A. G. Reaume and Jeffrey L. Elliott and E. Hoffman and Neil W. Kowall and Robert J. Ferrante and Donald R Siwek and Heide M. Wilcox and Dorothy G. Flood and M. Beal and Robert H. Brown and Richard W. Scott and W. Snider},
  journal={Nature Genetics},
  year={1996},
  volume={13},
  pages={43-47}
}
  • A. G. Reaume, Jeffrey L. Elliott, +9 authors W. Snider
  • Published 1996
  • Biology, Medicine
  • Nature Genetics
  • The discovery that some cases of familial amyotrophic lateral sclerosis (FALS) are associated with mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1) has focused much attention on the function of SOD1 as related to motor neuron survival. Here we describe the creation and characterization of mice completely deficient for this enzyme. These animals develop normally and show no overt motor deficits by 6 months in age. Histological examination of the spinal cord reveals no signs of… CONTINUE READING
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