Motor neuron-like NSC-34 cells as a new model for the study of vitamin D metabolism in the brain.

@article{Almokhtar2016MotorNN,
  title={Motor neuron-like NSC-34 cells as a new model for the study of vitamin D metabolism in the brain.},
  author={Mokhtar Almokhtar and Kjell Wikvall and Sarojini Jayantha Kumari A Ubhayasekera and Jonas Bergquist and Maria Norlin},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2016},
  volume={158},
  pages={178-188}
}
Vitamin D3 is a pro-hormone, which is sequentially activated by 25- and 1α-hydroxylation to form 25-hydroxyvitamin D3 [25(OH)D3] and 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3], respectively. Subsequent inactivation is performed by 24-hydroxylation. These reactions are carried out by a series of CYP450 enzymes. The 25-hydroxylation involves mainly CYP2R1 and CYP27A1, whereas 1α-hydroxylation and 24-hydroxylation are catalyzed by CYP27B1 and CYP24A1, respectively, and are tightly regulated to… CONTINUE READING
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