Motor neuron disease (amyotrophic lateral sclerosis) arising from longstanding primary lateral sclerosis.

@article{Bruyn1995MotorND,
  title={Motor neuron disease (amyotrophic lateral sclerosis) arising from longstanding primary lateral sclerosis.},
  author={Richard P. M. Bruyn and Johannes H. T. M. Koelman and Dirk Troost and J M B Vianney de Jong},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={1995},
  volume={58 6},
  pages={742-4}
}
Three men were initially diagnosed as having primary lateral sclerosis (PLS), but eventually developed amyotrophic lateral sclerosis (ALS) after 7.5, 9, and at least 27 years. Non-familial ALS and PLS might be different manifestations of a single disease or constitute completely distinct entities. The clinical diagnosis of PLS predicts a median survival that is four to five times longer than in ALS. 

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