Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation.

@article{Gurney1994MotorND,
  title={Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation.},
  author={Mark E Gurney and Hong Pu and Arlene Y. Chiu and Mauro C Dal Canto and C Y Polchow and Daniel C. Alexander and Janice Caliendo and Afif Hentati and Yong Wook Kwon and Han-Xiang Deng},
  journal={Science},
  year={1994},
  volume={264 5166},
  pages={1772-5}
}
Mutations of human Cu,Zn superoxide dismutase (SOD) are found in about 20 percent of patients with familial amyotrophic lateral sclerosis (ALS). Expression of high levels of human SOD containing a substitution of glycine to alanine at position 93--a change that has little effect on enzyme activity--caused motor neuron disease in transgenic mice. The mice became paralyzed in one or more limbs as a result of motor neuron loss from the spinal cord and died by 5 to 6 months of age. The results show… CONTINUE READING
Highly Influential
This paper has highly influenced 160 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
1,266 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 1,266 extracted citations

Similar Papers

Loading similar papers…