Motor function and regulation of myosin X.

  title={Motor function and regulation of myosin X.},
  author={Kazuaki Homma and Jun-ichi Saito and Reiko Ikebe and Mitsuo Ikebe},
  journal={The Journal of biological chemistry},
  volume={276 36},
Myosin X is a member of the diverse myosin superfamily that is ubiquitously expressed in various mammalian tissues. Although its association with actin in cells has been shown, little is known about its biochemical and mechanoenzymatic function at the molecular level. We expressed bovine myosin X containing the entire head, neck, and coiled-coil domain and purified bovine myosin X in Sf9 cells. The Mg(2+)-ATPase activity of myosin X was significantly activated by actin with low K(ATP). The… CONTINUE READING
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