Motor fluctuations in Parkinson's disease: central pathophysiological mechanisms, Part II.

@article{Mouradian1988MotorFI,
  title={Motor fluctuations in Parkinson's disease: central pathophysiological mechanisms, Part II.},
  author={Maral M Mouradian and Jorge L. Juncos and Giovanni Fabbrini and Jurgen Schlegel and John J. Bartko and Thomas N. Chase},
  journal={Annals of neurology},
  year={1988},
  volume={24 3},
  pages={372-8}
}
The contribution of central pharmacodynamic mechanisms to the pathogenesis of motor fluctuations in advanced Parkinson's disease was studied in 29 patients by evaluating their acute response to intravenously injected levodopa. While the threshold dose for an antiparkinsonian effect did not change, that for induction of dyskinesia showed a progressive reduction in 4 groups: (1) levodopa-naive patients, (2) those with a stable response to oral administration, and (3) those with wearing-off or (4… CONTINUE READING

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