Motor features in Parkinson's disease with normal olfactory function.


BACKGROUND Normosmic Parkinson's disease (PD) might be a unique clinical phenotype with a more benign course when compared with hyposmic PD. OBJECTIVE The objective of this study was to evaluate motor features and the acute levodopa response according to olfactory function. METHODS A total of 169 de novo PD patients that underwent olfactory testing and acute levodopa challenge for clinical prediction of sustained long-term dopaminergic response were evaluated. RESULTS The overall frequency of normosmia was 33%. Normosmic PD patients scored nonsignificantly different to hyposmic/anosmic patients on motor scale and on degree of improvement with levodopa. Motor scores at follow-up were comparable among groups. CONCLUSIONS Normal olfactory function is common in early PD and was not associated with a different motor phenotype when compared with PD patients with olfactory dysfunction. © 2016 International Parkinson and Movement Disorder Society.

DOI: 10.1002/mds.26687

Cite this paper

@article{Rossi2016MotorFI, title={Motor features in Parkinson's disease with normal olfactory function.}, author={Malco Rossi and Alex Medina Escobar and Andrea Bril and Patricio Millar Vernetti and Juan Ignacio De Palo and Daniel Cerquetti and Marcelo Merello}, journal={Movement disorders : official journal of the Movement Disorder Society}, year={2016}, volume={31 9}, pages={1414-7} }