Motor effects of acute and chronic inhibition of nitric oxide synthesis in mice

  title={Motor effects of acute and chronic inhibition of nitric oxide synthesis in mice},
  author={Elaine Aparecida Del Bel and Anselmo Souza and Fanny Guimaraes and CONSUELO DA-SILVA and L. P. Nucci-da-Silva},
Rationale: Systemic injections of nitric oxide synthase (NOS) inhibitors have been shown to decrease exploratory behavior in rats. This effect may be related to motor impairments since these drugs can induce catalepsy in rodents. Objective: To compare the effects of two NOS inhibitors in tests aimed to investigate exploratory behavior and to assess motor control. Methods: The acute effects of the NOS inhibitors NG-nitro-L-arginine (L-NOARG, 10–80 mg/kg IP) and 7-nitroindazole (7-NIO, 3–30 mg/kg… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 17 extracted citations

Myricitrin, a nitric oxide and protein kinase C inhibitor, exerts antipsychotic-like effects in animal models

Progress in Neuro-Psychopharmacology and Biological Psychiatry • 2011
View 8 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 43 references

Nitric oxide synthase inhibitors cause motor deficits in mice.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology • 2001

Coadministration of gammahydroxybutyric acid and L - NOARG : effects on catalepsy in mice medical

JF Navarro, C Pedraza, M Martin-Lopez, E Maldonado
Sci Res • 1998

Similar Papers

Loading similar papers…