Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice.

@article{GmezIsla2003MotorDA,
  title={Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice.},
  author={Teresa G{\'o}mez-Isla and Michael C. Irizarry and Ami Mariash and Bonnie S. Cheung and Oscar Mayor Soto and Stefanie E. Schrump and Jesse Sondel and Linda A. Kotilinek and John Day and Michael A. Schwarzschild and J J Cha and Kathy L Newell and David Wayne Miller and Kenji Ueda and Anne B. Young and Bradley T. Hyman and K. Ashe},
  journal={Neurobiology of aging},
  year={2003},
  volume={24 2},
  pages={245-58}
}
Alpha-synuclein is a major component of Lewy bodies (LBs) in the substantia nigra and cortex in Parkinson's disease (PD) and dementia with Lewy bodies (DLB), and in glial inclusions in multiple systems atrophy (MSA). Mutations in alpha-synuclein have been associated with autosomal dominant forms of PD. We investigated the clinical and neuropathological effects of overexpression of human alpha-synuclein, alpha-synuclein A30P, and alpha-synuclein A53T under the control of the hamster prion… CONTINUE READING
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