Motor domain-dependent localization of myo1b (myr-1)

  title={Motor domain-dependent localization of myo1b (myr-1)},
  author={Nanyun Tang and E Michael Ostap},
  journal={Current Biology},
Myosin-I is the single-headed, membrane binding member of the myosin superfamily that plays a role in membrane dynamics and transport [1-6]. Its molecular functions and its mechanism of regulation are not known. In mammalian cells, myosin-I is excluded from specific microfilament populations, indicating that its localization is tightly regulated. Identifying the mechanism of this localization, and the specific actin populations with which myosin-I interacts, is crucial to understanding the… CONTINUE READING