Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice.

@article{Watase1998MotorDA,
  title={Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice.},
  author={Kei Watase and Koichi Hashimoto and Masanobu Kano and Kazuyuki Yamada and Masahiko Watanabe and Yoshiro Inoue and Shinichi Okuyama and T. Sakagawa and Sonoko Ogawa and Noritaka Kawashima and Satoko Hori and Misato Takimoto and Keiji Wada and Kohichi Tanaka},
  journal={The European journal of neuroscience},
  year={1998},
  volume={10 3},
  pages={976-88}
}
To study the function of GLAST, a glutamate transporter highly expressed in the cerebellar Bergmann astrocytes, the mouse GLAST gene was inactivated. GLAST-deficient mice developed normally and could manage simple coordinated tasks, such as staying on a stationary or a slowly rotating rod, but failed more challenging task such as staying on a quickly rotating rod. Electrophysiological examination revealed that Purkinje cells in the mutant mice remained to be multiply innervated by climbing… CONTINUE READING