Motor deficits associated with Huntington's disease occur in the absence of striatal degeneration in BACHD transgenic mice.

@article{Mantovani2016MotorDA,
  title={Motor deficits associated with Huntington's disease occur in the absence of striatal degeneration in BACHD transgenic mice.},
  author={Susanna Mantovani and Richard Gordon and Rui Li and Daniel C Christie and Vinod Kumar and Trent M Woodruff},
  journal={Human molecular genetics},
  year={2016},
  volume={25 9},
  pages={1780-91}
}
Huntington's disease (HD) is an incurable neurodegenerative condition characterized by progressive motor and cognitive dysfunction, and depletion of neurons in the striatum. Recently, BACHD transgenic mice expressing the full-length human huntingtin gene have been generated, which recapitulate some of the motor and cognitive deficits seen in HD. In this study, we carried out a series of extensive behavioural and neuropathological tests on BACHD mice, to validate this mouse for preclinical… CONTINUE READING