Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1

@article{Conquet1994MotorDA,
  title={Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1},
  author={François Conquet and Z I Bashir and Ceri H. Davies and Hervé Daniel and Francesco Ferraguti and Fabio Bordi and Karin Franz-Bacon and Angelo Reggiani and Valerie Matarese and Françoise Cond{\'e} and Graham L. Collingridge and Francis Crépel},
  journal={Nature},
  year={1994},
  volume={372},
  pages={237-243}
}
Metabotropic glutamate receptor 1 (mGluRl) is a member of a large family of G-protein-coupled glutamate receptors, the physiological functions of which are largely unknown. Mice deficient in mGluRl have severe motor coordination and spatial learning deficits. They have no gross anatomical or basic electrophysiological abnormalities in either the cerebellum or hippocampus, but they show impaired cerebellar long-term depression and hippocampal mossy fibre long-term potentiation. mGluRl-deficient… 
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The mGLU receptors modulate the multiple forms of synaptic plasticity at both SC-CA1 and MF synapses and allosteric modulators of mGlu receptors have emerged as potential therapeutic agents that may rescue plasticity deficits and improve cognitive function in patients suffering from multiple neurological and psychiatric disorders.
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Altered Short-Term Synaptic Plasticity in Mice Lacking the Metabotropic Glutamate Receptor mGlu7
TLDR
Results show that the absence of mGlu7 receptors results in alterations in short-term synaptic plasticity in the hippocampus, and this results shows that the Schaffer collateral-commissural pathway displays robust long-term potentiation (LTP).
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