Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1

@article{Conquet1994MotorDA,
  title={Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1},
  author={François Conquet and Z I Bashir and Ceri H. Davies and Hervé Daniel and Francesco Ferraguti and Fabio Bordi and Karin Franz-Bacon and Angelo Reggiani and Valerie Matarese and Françoise Cond{\'e} and Graham L. Collingridge and Francis Crépel},
  journal={Nature},
  year={1994},
  volume={372},
  pages={237-243}
}
Metabotropic glutamate receptor 1 (mGluRl) is a member of a large family of G-protein-coupled glutamate receptors, the physiological functions of which are largely unknown. Mice deficient in mGluRl have severe motor coordination and spatial learning deficits. They have no gross anatomical or basic electrophysiological abnormalities in either the cerebellum or hippocampus, but they show impaired cerebellar long-term depression and hippocampal mossy fibre long-term potentiation. mGluRl-deficient… 
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734 Citations
Highly Influential Citations
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Methods Citations
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Results Citations
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734 Citations

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Citation Type

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TLDR
It is proposed that mGluR1 in PCs is a key molecule for normal synapse formation, synaptic plasticity, and motor control in the cerebellum.
Impaired Cerebellar Synaptic Plasticity and Motor Performance in Mice Lacking the mGluR4 Subtype of Metabotropic Glutamate Receptor
TLDR
The results indicate that an important function of mGluR4 is to provide a presynaptic mechanism for maintaining synaptic efficacy during repetitive activation, and suggest that the presence ofmGLUR4 at the parallel fiber→Purkinje cell synapse is required for maintaining normal motor function.
Reduced long-term potentiation in the dentate gyrus of mGlu1 receptor-mutant mice in vivo.
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    European journal of pharmacology
  • 1996
Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease
TLDR
Emerging evidence that altered mGluR1 signaling in Purkinje cells underlies cerebellar dysfunctions in several clinically relevant mouse models of human ataxias is described.
Mice Lacking Metabotropic Glutamate Receptor 5 Show Impaired Learning and Reduced CA1 Long-Term Potentiation (LTP) But Normal CA3 LTP
TLDR
Long-term potentiation (LTP) in mGluR5 mutants was significantly reduced in the NMDA receptor (NMDAR)-dependent pathways such as the CA1 region and dentate gyrus of the hippocampus, whereas LTP remained intact in the mossy fiber synapses on the CA3 region, an NMDAR-independent pathway.
The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory
Metabotropic glutamate receptor subtype-1 is essential for motor coordination in the adult cerebellum
The Role of mGlu Receptors in Hippocampal Plasticity Deficits in Neurological and Psychiatric Disorders: Implications for Allosteric Modulators as Novel Therapeutic Strategies
TLDR
The mGLU receptors modulate the multiple forms of synaptic plasticity at both SC-CA1 and MF synapses and allosteric modulators of mGlu receptors have emerged as potential therapeutic agents that may rescue plasticity deficits and improve cognitive function in patients suffering from multiple neurological and psychiatric disorders.
Roles of metabotropic glutamate receptors in LTP and LTD in
Altered Short-Term Synaptic Plasticity in Mice Lacking the Metabotropic Glutamate Receptor mGlu7
TLDR
Results show that the absence of mGlu7 receptors results in alterations in short-term synaptic plasticity in the hippocampus, and this results shows that the Schaffer collateral-commissural pathway displays robust long-term potentiation (LTP).
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