Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1

@article{Conquet1994MotorDA,
  title={Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1},
  author={François Conquet and Z I Bashir and Ceri H. Davies and Hervé Daniel and Francesco Ferraguti and Fabio Bordi and Karin Franz-Bacon and Angelo Reggiani and Valerie Matarese and Françoise Cond{\'e} and Graham L. Collingridge and Francis Crépel},
  journal={Nature},
  year={1994},
  volume={372},
  pages={237-243}
}
Metabotropic glutamate receptor 1 (mGluRl) is a member of a large family of G-protein-coupled glutamate receptors, the physiological functions of which are largely unknown. Mice deficient in mGluRl have severe motor coordination and spatial learning deficits. They have no gross anatomical or basic electrophysiological abnormalities in either the cerebellum or hippocampus, but they show impaired cerebellar long-term depression and hippocampal mossy fibre long-term potentiation. mGluRl-deficient… 
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