Motor and tail homology 1 (Th1) domains antagonistically control myosin-1 dynamics.

@article{Mazerik2014MotorAT,
  title={Motor and tail homology 1 (Th1) domains antagonistically control myosin-1 dynamics.},
  author={Jessica N. Mazerik and Lewis J. Kraft and A. Kenworthy and M. Tyska},
  journal={Biophysical journal},
  year={2014},
  volume={106 3},
  pages={
          649-58
        }
}
Class 1 myosins are monomeric motor proteins that fulfill diverse functions at the membrane/cytoskeletal interface. All myosins-1 contain a motor domain, which binds actin, hydrolyzes ATP, and generates forces, and a TH1 domain, which interacts directly with membrane lipids. In most cases, TH1 is needed for proper subcellular localization and presumably function, although little is known about how this domain regulates the behavior of class 1 myosins in live cells. To address this, we used… Expand
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