Motor and non-motor features of Parkinson's disease - a review of clinical and experimental studies.

@article{Lima2012MotorAN,
  title={Motor and non-motor features of Parkinson's disease - a review of clinical and experimental studies.},
  author={Marcelo M S Lima and Emerson Fachin Martins and Ana Marci Delattre and Mariana Bordinh{\~a}o Proença and Marco Aur{\'e}lio Mori and Bruno Carabelli and Anete Curte Ferraz},
  journal={CNS & neurological disorders drug targets},
  year={2012},
  volume={11 4},
  pages={
          439-49
        }
}
Classically, Parkinson's disease (PD) is considered to be a motor system affliction and its diagnosis is based on the presence of a set of cardinal motor signs (e.g. rigidity, bradykinesia, rest tremor and postural reflex disturbance). However, there is considerable evidence showing that non-motor alterations (e.g. anxiety, depression, sleep, gastrointestinal and cognitive functions) precede the classical motor symptoms seen in PD. The management of these nonmotor symptoms remains a challenge… CONTINUE READING

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