Motor and behavioral changes in mice with cisplatin-induced acute renal failure.

@article{Ali2014MotorAB,
  title={Motor and behavioral changes in mice with cisplatin-induced acute renal failure.},
  author={Badreldin H Ali and Aishwarya Ramkumar and Thulasi Madanagopal and Mostafa Waly and M. Elhosseini Tageldin and Saif Al-Abri and Mohammad Fahim and Javed Yasin and Abderrahim Nemmar},
  journal={Physiological research},
  year={2014},
  volume={63 1},
  pages={35-45}
}
We have previously shown that chronic renal failure in rats induces changes in motor activity and behavior. Similar work on the possible effects of acute renal failure (ARF) induced by cisplatin (CP) is lacking. This is the subject matter of the current work. CP was injected intraperitoneally (i.p.) at a single dose of 20 mg/kg to induce a state of ARF, and three days later, its effects on motor activity, thermal and chemical nociceptive tests, neuromuscular coordination, pentobarbitone… CONTINUE READING
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