Motor Unit Number Index (MUNIX) detects motor neuron loss in pre-symptomatic muscles in Amyotrophic Lateral Sclerosis

@article{Neuwirth2017MotorUN,
  title={Motor Unit Number Index (MUNIX) detects motor neuron loss in pre-symptomatic muscles in Amyotrophic Lateral Sclerosis},
  author={Christoph Neuwirth and Paul E. Barkhaus and Christian Burkhardt and J. Castro and Markus Weber},
  journal={Clinical Neurophysiology},
  year={2017},
  volume={128},
  pages={495-500}
}
OBJECTIVE Motor Unit Number Index (MUNIX) is a quantitative neurophysiological measure that provides an index of the number of lower motor neurons supplying a muscle. It reflects the loss of motor neurons in patients with Amyotrophic Lateral Sclerosis (ALS). However, it is unclear whether MUNIX also detects motor unit loss in strong, non-wasted muscles. METHODS Three centres measured MUNIX in 49 ALS patients every three months in six different muscles (abductor pollicis brevis, abductor… CONTINUE READING

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