Motor Recovery and Cortical Reorganization after Constraint-Induced Movement Therapy in Stroke Patients: A Preliminary Study

@article{Schaechter2002MotorRA,
  title={Motor Recovery and Cortical Reorganization after Constraint-Induced Movement Therapy in Stroke Patients: A Preliminary Study},
  author={J. Schaechter and E. Kraft and T. Hilliard and R. Dijkhuizen and T. Benner and S. Finklestein and B. Rosen and S. Cramer},
  journal={Neurorehabilitation and Neural Repair},
  year={2002},
  volume={16},
  pages={326 - 338}
}
Constraint-induced movement therapy (CIMT) is a physical rehabilitation regime that has been previously shown to improve motor function in chronic hemiparetic stroke patients. However, the neural mechanisms supporting rehabilitation-induced motor recovery are poorly understood. The goal of this study was to assess motor cortical reorganization after CIMT using functional magnetic resonance imaging (fMRI). In a repeated-measures design, 4 incompletely recovered chronic stroke patients treated… Expand
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TLDR
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TLDR
CIMT could significantly improve the upper limb movement function of stroke patients and fMRI proved that this kind of change was related with the plasticity change of the cerebrum. Expand
Retrospective Exploratory Analysis of Task-Specific Effects on Brain Activity after Stroke
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TLDR
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TLDR
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References

SHOWING 1-10 OF 59 REFERENCES
Motor cortex plasticity during constraint-induced movement therapy in stroke patients
TLDR
Even in chronic stroke patients, reduced motor cortex representations of an affected body part can be enlarged and increased in level of excitability by an effective rehabilitation procedure, demonstrating a CNS correlate of therapy-induced recovery of function after nervous system damage in humans. Expand
Functional MRI Evidence of Cortical Reorganization in Upper-Limb Stroke Hemiplegia Treated with Constraint-Induced Movement Therapy
TLDR
Constraint-induced movement therapy produced significant functional improvement and resulted in plasticity as demonstrated by functional MRI. Expand
Pilot study of functional MRI to assess cerebral activation of motor function after poststroke hemiparesis.
TLDR
The explanation offered for the findings is that preexisting uncrossed motor neural pathways may be accessed or recruited to compensate for damage to the crossed motor pathways after ischemic stroke. Expand
Treatment-induced cortical reorganization after stroke in humans.
TLDR
This is the first demonstration in humans of a long-term alteration in brain function associated with a therapy-induced improvement in the rehabilitation of movement after neurological injury. Expand
Evolution of cortical activation during recovery from corticospinal tract infarction.
TLDR
The evolution of activation in the SMC from early contralesional activity to late ipsilesional activity suggests that a dynamic bihemispheric reorganization of motor networks occurs during recovery from hemiparesis. Expand
A Functional MRI Study of Three Motor Tasks in the Evaluation of Stroke Recovery
TLDR
MRI was used to evaluate control subjects and patients with good recov ery after a left hemisphere hemiparetic stroke and found activation in left sensorimotor cortex was found to be significantly larger during squeezing as compared with index-finger tapping. Expand
Plasticity in the motor system related to therapy-induced improvement of movement after stroke.
TLDR
This long-term change in source locations associated with affected hand movement may be considered as an initial demonstration of large-scale neuroplasticity associated with increased use of the paretic limb after application of CI therapy. Expand
A functional MRI study of subjects recovered from hemiparetic stroke.
TLDR
Recovered finger-tapping by stroke subjects activated the same motor regions as controls but to a larger extent, particularly in the unaffected hemisphere, which indicates increased reliance on these motor areas may represent an important component of motor recovery. Expand
Mirror Movements Complicate Interpretation of Cerebral Activation Changes during Recovery from Subcortical Infarction
TLDR
Assessment of cerebral activation during motor activity longitudinally after hemiparesis due to cerebral infarction found activation of motor areas in the hemisphere ipsilateral to the affected limb roughly correlated with presence of mirror movements. Expand
Ipsilateral activation of the unaffected motor cortex in patients with hemiparetic stroke
TLDR
TMS reveals a specific area in the motor cortex from which ipsilateral MEPs can be elicited and both TMS and TCD indicate that an ips bilateral corticospinal tract can be accessible in some adult controls or becomes unmasked after cerebral damage. Expand
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