Motor Number Controls Cargo Switching at Actin-Microtubule Intersections In Vitro

@article{Schroeder2010MotorNC,
  title={Motor Number Controls Cargo Switching at Actin-Microtubule Intersections In Vitro},
  author={Harry W. Schroeder and Chris Mitchell and Henry Shuman and Erika L. F. Holzbaur and Yale E. Goldman},
  journal={Current Biology},
  year={2010},
  volume={20},
  pages={687-696}
}
BACKGROUND Cellular activities such as endocytosis and secretion require that cargos actively switch between the microtubule (MT) and actin filament (AF) networks. Cellular studies suggest that switching may involve a tug of war or coordinate regulation of MT- and AF-based motor function. RESULTS To test the hypothesis that motor number can be used to direct the outcome of a tug-of-war process, we reconstituted cargo switching at MT-AF intersections in a minimal system with purified myosin V… CONTINUE READING

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